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Exploring gender differences in HIV risk behavior, Kenagy and Hsieh (2005) analyzed survey data from 122 male-to-female (MTF) transgenders and 62 female-to-male (FTM) transgenders . Notably, "[c]ompared to MTFs, FTMs were significantly less likely to have used protection the last time they had sex and significantly more likely to have engaged in recent high risk sexual activity. The gender difference existed even after controlling for demographic variables, AIDS knowledge, perceived AIDS knowledge, perceived effectiveness of condom usage, perceived susceptibility to AIDS and self-esteem" (p. 195). Acknowledging that the generalizability of these findings is limited because of the sampling techniques involved and the oversimplification of gender identity into only two categories, Kenagy and Hsieh nonetheless urge clinicians to assess sexual activities thoroughly to identify HIV risk behaviors, review safer sexual practices, and encourage HIV testing among FTM transgenders so that informed decisions regarding sexual activities can be made.

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